米索前列醇对大鼠抗早孕药理研究  

A Pharmacological Study of the effeet of Misoprostol on the Termination of Early Pregnancy in Rats

作　　者：刘昌官[1] 褚军[1] 吴晓云[1] 

机构地区：[1]上海市计划生育科学研究所

出　　处：《生殖与避孕》1995年第1期47-52,共6页Reproduction and Contraception

摘　　要：米索前列醇对大鼠子宫有明显的收缩作用。米索随着剂量由５００、２０００增至４０００μｇ／ｋｇ，兔子宫内压由弱到强，收缩频率由慢加快。米索５００μｇ／ｋｇ和米非司酮２０００μｇ／ｋｇ合用后对妊娠兔子宫内压加强，收缩频率加快，而米非司酮能提高子宫肌的敏感性。小鼠口服米索的半数有效量（ＥＤ５０）为１６００（９００～２７００）μｇ／ｋｇ，单用口服米非司酮及分别与米索４００、８Ｏ０和１２００μｇ／ｋｇ合用时半数有效量依次为４１３．５、２２６．５、２０６．０和１４２．０μｇ／ｋｇ。米索对大鼠完全无终止妊娠作用；单用口服来非司酮及分别与来索４００、８００和１２００μｇ／ｋｇ合用时半数有效量依次为２４３０．５、５８９．４、４３７．２和３７６．５μｇ／ｋｇ。It was obvious that misoprostol caused uterine contraction in rats. Its intrinsic pressure and contractive frequency of rabbit uterus were incressed due to the increment of dosage of misoprostol ranging from 500 μg/kg.2000μg/kg to 4000μg/kg. The misoprostol at a dosage of 500μg/kgcombined with mifepristone 2000μg/kg could increase the intrinsic pressure and contractive frequency in rabbit uterus. The result showed that the mifepristone could increase the sensitivity of uterns.The ED50 of oral dosage of the misoprostol in mice was 1600 (800～2700)μg/kg and the ED50of oral dosage of mifepristone in mice was 413. 5μg/kg. The combination of mifepristone with misoprostol administration at the doses of 400. 800 and 1200μg/kg, the ED50 of oral dosage of mifepristion in mice was 226. 5、206. 0 and 142. 0μg/kg respectively. No effect of misoprostol on termination of early pregnancy in rats could be found. The ED50 of oral dosage of mifepristone in rats was 2430. 5μg/kg,In case of the combined administration of mifepristone and misoprostol ofthe dosage of 400、800 and 1200μg/kg, the ED50 of oral admilnistration mifeprostone in rats was 589. 4、437. 2 and 376. 5μg/kg respectively.

关 键 词：米索前列醇 米非司酮 抗早孕 药理 

分 类 号：R979.21[医药卫生—药品]