米非司酮对兔输卵管、子宫平滑肌收缩及前列腺素含量影响  

Effect of Mifepristone on Oviductal and Uterine ContractileActivities and Their PGs contents in Pseudopregnant Rabbits

作　　者：奚明[1] 杨丽珍[1] 沈颖[1] 谢衷明[1] 

机构地区：[1]上海市计划生育科学研究所,国家计划生育药具重点实验室,江西医学院生理教研室

出　　处：《生殖与避孕》1995年第2期117-121,共5页Reproduction and Contraception

摘　　要：本文通过肌肉收缩记录方法和放射免疫技术研究米非司酮对４天假孕兔输卵管、子宫平滑肌收缩及前列腺素含量影响。结果：米非司酮能干扰输卵管平滑肌自发收缩，收缩频率明显增加，收缩张力及振幅却无明显变化；输卵管对前列腺素Ｅ衍生物磺前列酮的敏感性提高，而对去甲肾上腺素的敏感性降低；输卵管组织前列腺素Ｆ２α含量下降，使ＰＧＥ／ＰＧＦ比值上升；但对子宫平滑肌收缩及组织内前列腺素Ｅ与Ｆ比值无明显影响。以上现象提示米非司酮可能通过改变体内雌、孕激素平衡及前列腺素Ｅ、Ｆ平衡等多种途径对输卵管平滑肌活动产生综合性作用。The effect of Mifepristone on oviductal and uterine contractilities and their PGs contents wasobserved by using isolated muscular contractile recorder and radioimmunoassay technique.The results showed that Mifepristone could interfer the oviductal smooth muscular contractility,it increased the contractile frequency (P<0.05),but not the contractile tension. It enhenced also thesensitivity of smooth muscle to PGE derivative-sulprostone,but reduced the sensitivity of thesmooth muscle to norepinephrine(NE). Mifepristone reduced the oviductal PGF2α content significantly (P<0.05),it caused the ratio of PG E/F to rise (P<0.001);However,Mifepristone didnot obviously influence the uterine smooth muscular contractility and the ratio of PG E/F.The results suggested that Mifepristone may influence the oviductal muscular function through variousroutes to give a comprehensive action.

关 键 词：米非司酮 输卵管 子宫收缩 前列腺素 

分 类 号：R979.21[医药卫生—药品]