检测尿HBV抗原诊断乙型肝炎相关性肾炎的价值  

Diagnosis of glomerulonephritis associated with hepatitis B virus by using examination of Hepatitis B Virus antigen in urine

作　　者：张恒言[1] 李永柏[1] 李秋[1] 梁大才[1] 徐培菊[1] 唐宜[1] 廖晓岗[1] 史景泉[1] 王晓东[1] 

机构地区：[1]重庆医科大学附属儿童医院,重庆医科大学附属儿童医院电子显微镜室,第三军医大学病理解剖教研室

出　　处：《实用儿科临床杂志》1995年第6期321-323,共3页Journal of Applied Clinical Pediatrics

摘　　要：研究目的探讨检测尿乙型肝炎病毒（ＨＢＶ）抗原诊断乙型肝炎相关性肾炎（乙肝肾炎）的价值。研究方法经临床、血清及肾活检ＨＢＶ抗原诊断为乙肝肾炎患者；与测这些乙肝肾炎患者尿ＨＢＶ抗原结果进行比较研究。结果２３例乙肝肾炎肾小球内ＨＢｓＡｇ阳性率７８．３％（１８／２３），ＨＢｃＡｇ阳性率２１．７％（５／２３）。血清ＨＢｓＡｇ阳性率８７％（２０／２３）。尿ＨＢｓＡｇ阳性率７８．３％（１８／２３）。表明乙肝肾炎患者的尿、血清及肾小球内ＨＢｓＡｇ阳性率之间无显著差别（Ｐ＞０．５０）。结论肾小球病伴尿ＨＢＶ抗原阳性者可临床诊断乙肝肾炎。Objective Hepatitis B Virus antigen in urine was examined for the diagnosis of glomerulonephritisassociated with Hepatitis B Virus,and its Value in clinic is to be probed.Method A comparative method of studying on the diagnosis of glomerulonephritis associated with He patitis B Virus by using examination of Hepatitit B Virus antigen in serum, urine and glomeruli fromkidney biopsy is proposed.Result For diagnosis of glomerulonephritis associted with Hepatitis B Virus 23 cases were examined,the result shows that the positive percentage of HBsAg in the patients'serum is 87% (20/23),that of HBsAg. HBcAg in the patients'glomeruli from kidney biopsy are 78.3% (18/23).21.7% (5/23) respectively, and that of HBsAg in the patients'urine is 78.3% (18/23).There are no significant difference between the percentage of HBsAg in patients'urine.Serum and glomeruli from kidney biopsy (p>0.50).Conclusion So it is possible in clinic for diagnosis glomerulonephritis associated with hepatitis B Virus when patient of glomerulopathy with Hepatitis B Virus antigen in the patient's urine in examined positively.

关 键 词：乙型肝炎抗原 肾炎 尿液检验 

分 类 号：R692.390.4[医药卫生—泌尿科学] R512.620.6[医药卫生—外科学]