免疫反应对糖皮质激素受体的调控及其意义  

INFLUENCES OF IMMUNE RESPONSE ON GLUCOCORTICOID

作　　者：唐术成[1] 苏宝田[1] 史敏言[1] 

机构地区：[1]安徽医科大学病理生理教研室,合肥230032

出　　处：《中国免疫学杂志》1989年第5期272-274,共3页Chinese Journal of Immunology

摘　　要：本文采用绵羊红细胞(SRBC)经腹腔注入C_(57)BL小鼠作为免疫反应模型,观察小鼠在免疫反应中脾脏细胞糖皮质激素受体(GCR)数的变化,发现自SRBC致敏后第五天始小鼠脾脏细胞GCR数明显高于对照组(P<0.005),第七天达高峰,第十一天恢复至正常水平。地塞米松对致敏组和对照组小鼠脾脏细胞由PHA诱导的淋巴细胞转化抑制程度的明显差异可能与脾脏细胞GCR数变化有关。本文还用上述方法研究了妊娠小鼠,发现妊娠小鼠脾脏细胞GCR数明显高于未妊娠小鼠(P<0.05),这在调节母胎免疫反应中具有重要意义。In our report the results obtained areas follows:(1)plasma corticosteronelevel in C_(57)BL mice immunized bySRBC was higher than control(P<0.05)in response to SRBC;(2)Thesupernatant from human peripheralblood lymphocytes stimulated byPHA or ConA increased mice plasmcorticosterone level (P<0.02);(3)pl-asma corticosterone level in pregnantmice was higher than unpregnantmice(P<0.005);(4)There mightexist a kind of immunoreactivechronic gonadotropin in immunesystem;which suggest that immunesystem regulate neuroendocrine sys-tem by active transmition and theyaltogether formed immune-neuroen-docrine regulation network and takepart in the body general physiologi cal regulation.I

关 键 词：免疫反应 GCR 妊娠 

分 类 号：R371.2[医药卫生—病原生物学]