乌梅─枸椽酸的杀精作用及被杀伤精子的透射电镜观察  

THE SPERMICIDAL POTENCY OF THE ACIDUM CITRICUM FRUCTUS MUME AND TEM OBSERVATION ON AN AFFLECTED SPERM

作　　者：程传芬 黄庆玉 张金池 朱维成 周翠环 

机构地区：[1]泰山区计划生育服务站

出　　处：《泰山医学院学报》1995年第2期77-81,共5页Journal of Taishan Medical College

摘　　要：为尽快研制成高效、无毒、价格低廉的新型杀精子剂，我们从５０余种传统中草药中筛选出杀精效果较好（ｌ分钟内使精子瞬间失活）的中药乌梅。经化学分析、提纯，确定其杀精有效成分为枸椽酸。其最低有效杀精浓度为０．０９％，经透射电镜观察证明：乌梅─枸椽酸杀伤精子的主要靶结构是精子顶体、质膜、核膜及线粒体，损伤核的遗传物质，使线粒体空泡变性，嵴崩解或者溶解。并证明乌梅─枸椽酸药液的浓度不同，上述结构损伤程度也不同。In order to develop as soon as possible a new kind of spermatocide,which is effica-ciou,nonpoisonous and cheap,the authors selected prunus mume,which possesses a better spermicidalpotency,out of more than fifty kinds of Chinese traditional and herbal drugs.(All the afflicted spermswere within a minute of their death.)After refined analysis,we ascertained that the spermicidal compo-sition of prunus mume was the acidum citricum fructus mume.Its minimum effective concentrationwas0.09%. TEM observation showed that the main target structures were acrosome,plasma mem-brane,nuclear membrane and mitochondrion.The spermatocide caused genetic damage,made the mito-chondrion degenerate ,disrupted or dissolved the ridge.The changes above vary with the concentration.

关 键 词：避孕药 中药 杀精子剂 乌梅-枸椽酸 顶体 线粒体 

分 类 号：R286.92[医药卫生—中药学]