水凝胶HFMC及其杀精子功能  

HYDROGEL HFMC IN SPERMICIDE

作　　者：徐若璞[1] 张文传[1] 邓正华[1] 罗自强[2] 曾怀德[2] 王有琪[2] 唐科士[2] 

机构地区：[1]中国科学院成都有机化学研究所 [2]华西医科大学

出　　处：《中国生物医学工程学报》1989年第2期63-67,共5页Chinese Journal of Biomedical Engineering

摘　　要：本文介绍一种带有羧基的甲基丙烯酸羟乙酯水凝胶HFMC的某些物性及其用于兔避孕的实验结果。精液检测及配对实验表明HFMC的杀精子功能是令人满意的。输精管的电镜观察表明,该水凝胶借助于输精管内的指状突起以一种生物体可接受的异物固着于管腔内,并呈多孔状而允许精子通过。HFMC对兔精子有严重损伤。NIH小鼠骨髓微核的观察表明HFMC用于体内是安全的。HFMC的组份对其沉淀形态及在生理盐水中的溶解度有明显影响,其羧基与羟基的比率保持在35～50％较为合适。<ABSTRACT> A spermicidal biomaterial HFMC which is a hydrogel based on poly- hydroxyethyl methacrylate with carboxyl group was tested in rabbit. The results of sperm determination and mating show that HFMC is satisfacto- ry as spermicide. Observations on vas deferens with electron micro graph show that a lots of pits are favorable to keep holding HFMC and he rabbit's spermatozoa can pass through the porous HFMC in the lumen. The membrance of spermatozoa contacted with HFMC was swollen and interrupted. Observation on HFMC in induction of micronucleus rate of polychromatic erythrocyte in bone marrow of NIH mice show that HFMC is safe in vivo. The morphology of deposit and solubility in saline depend on the compositions of HFMC. It is favorable to remain a rate of carbo- xyl and hydroxyl group in HFMC in the range of 35-50%.

关 键 词：HFMC 杀精子功能 羧基 

分 类 号：R318.08[医药卫生—生物医学工程]