用核孔滤膜在等负压条件下研究红细胞变形能力的理论分析  

THEORETICAL ANALYSIS FOR STUDY OFRED CELL DEFORMABILITYUSING NUCLEOPORE FILTERUNDER CONSTANT SUCTION PRESSURE

作　　者：严宗毅[1] 董立奇 钱民全[3] 翁维良[4] 王怡[4] 

机构地区：[1]北京大学力学系 [2]太原工业大学数力系 [3]中国科学院力学研究所 [4]中国中医研究院西苑医院

出　　处：《中国生物医学工程学报》1989年第2期86-95,共10页Chinese Journal of Biomedical Engineering

基　　金：国家自然科学基金资助项目

摘　　要：在临床上检验红细胞的变形能力已广泛作为诊断的辅助手段。检验方法之一是让红细胞稀悬浮液在等负压下通过核孔滤膜过滤。本文针对这一试验提出了一个生物流体力学模型,用两个参数β和ε来描述红细胞的变形能力,其中β是红细胞通过单个孔时的相对阻力,ε是红细胞使孔堵塞的概率。本文揭示了这两个参数对于过滤流量随时间变化规律的不同影响。根据这一不同点,本文导出了简单的公式可由实验数据算出β和ε。理论计算曲线与实验数据对比表明,本文提出的双参数模型能比通常采用的单个总体参数“过滤指数”(IF)更全面细致地描述红细胞变形能力。<ABSTRACT> The red cell deformability (RCD ) has been widely tested and taken as a diagnostic aid in clinical practice. One of such tests is the filtra- tion of dilute red cell suspension through a nucleopore filter under con- stant suction pressure. For this test the present paper proposes a biofluid mechanical model, in which the RCD are discribed by two parameters, the relative resistance 6 of a red cell passing a single pore and the probability ε of its plugging the pore. Different effects of the two para- meters on the change of filtration flux with time are demonstrated. Ba- sed on this difference, simple formulas are derived to compute β and ε from the experimental data. Comparison between the theoretically comp - uted curves and the experimental data shows that the two-parameter modek proposed herein can describe the RCD more comprehensively and in more details than the traditional global parameter 'filtration index' (IF ).

关 键 词：核孔滤膜 红细胞 生物流体力学 

分 类 号：R318.01[医药卫生—生物医学工程]