硅橡胶管对犬气管创面愈合的影响  

EFFECTS OF SILICON RUBBER TUBE ON HEALING OFTRACHEAL WOUNES IN DOGS

作　　者：王智[1] 迟汝澄[1] 陈文弦[1] 

机构地区：[1]第四军医大学唐都医院耳鼻咽喉科

出　　处：《中国生物医学工程学报》1989年第2期76-81,共6页Chinese Journal of Biomedical Engineering

摘　　要：本实验剥离并切去了12只犬气管一小块粘膜,其中8只犬术后在气管内放置了硅橡胶管为实验组,4只犬未放作为对照组。通过普通光镜和扫描电镜,观察了该管对气管创面及对正常粘膜的影响。发现:1.放管后,创面愈合过程正常,唯速度明显减慢;取管后,创面上完全恢复了正常的气管上皮。2.20×5mm之创面放管42天,鳞状上皮完全覆盖了创面,取管后28天,该上皮转变为纤毛柱状上皮。3.放管后,正常的气管上皮仍为假复层柱状细胞,但其表面之纤毛全部消失,取管后,纤毛可完全恢复。4.硅橡胶是比较理想的支撑喉气管的材料。<ABSTRACT> After a slice of tracheal mucosa was stripped off and resected in each of 12 dogs, silicon rubber tube was placed in trachea of each of 8 dogs (experimental) and the other 4 without tube insertion (control). Effect of the tube on healing process of tracheal wound and normal mucosa were studied with both light and electron microscope and results showed that: (1)rate of wound healing was apparently retarded in the experimen- tal group with restoration of healing process to normal after tube extrac- tion; (2) wound (20×5mm2 ) was completely covered by squamous cells 42 d after tube insertion and changed into ciliated columnar epithelia 28 d after tube extraction; (3) the epithelia of normal tracheal mucosa were pseudomultilayer columnar in nature without cilium after tube insertion with recovery of cilia after tube extraction; and (4) silicon rubber is an ideal material to be used as laryngotracheal strut tube.

关 键 词：硅橡胶管 犬气管 喉气管外伤 

分 类 号：R318.13[医药卫生—生物医学工程]