慢性乙型肝炎病人注射α-干扰素后2-5AS活性动态变化及其临床意义  

PBMc 2' ,5' -Oljgoadenylate Synthetase Activity and Its Clinical Significance during Interferon Treatment for Chronic Hepatitis B

作　　者：安萍[1] 秦绍明 杨开宇[2] 夏晓叶 邓燕林[1] 

机构地区：[1]北京军区总医院肝病研究所,100700 [2]中国科学院微生物研究所

出　　处：《天津医药》1995年第3期147-149,共3页Tianjin Medical Journal

摘　　要：21例(13例慢性活动型肝炎,8例慢性迁延性肝炎)慢性乙型肝炎用干扰素(IFN)治疗后,研究HBV DNA、DNA聚合酶活力(DNA-P),血清HBeAg水平及末悄血2′,5′A合成酶(2-5AS)的关系。用IFN后2-5AS在3小时内开始上升,12～24小时达高峰。经IFN治疗HBV DNA、DNA-P和HBeAg转阴的患者,其2-5AS活力比不转阴者明显增加,二者有非常显著性差异。结果提示:2-5AS活力可以预测干扰素治疗的疗效、是用作治疗前预测对干扰素应答的一个指标。Twenty-one patients (13 of CAH and 8 of CPU) with chronic hepatitis B were treated with mterferon(IEN). The purpose was to study relationships between HBV DNA and activity of serum DNA polvmerase(DNA-p) associated with HBV and between serum levels of HBeAg and activity of 2' ,5'ohgoadenylate synrhetase (2-5AS) in peripheral blood mononuclear cell(PBMC). When IFN was adimmistered, level of 2-5AS began to rise within 3 hr, reached peak value at 12-24 hr and then declined. This enzyme activity in the patients who became negative for HBV DNA,DNA-p and HBeAg after IFN treatment increased more than in patients who did not became negative. The increase of the enzyme activity in the two groups; was significantly different. These results suggest that 2-5AS activity could he used to predict the antiviral effect of IFN and being an index to predict the response before treatment.

关 键 词：干扰素 乙型肝炎 药物疗法 疗效 2-5AS 

分 类 号：R512.620.5[医药卫生—内科学]