脑损伤后自由基对远端脏器的损害作用  

Harmful Action of Free Radicals on Organs after Brain Injuries

作　　者：黄英雄[1] 樊丰势[1] 卢圣奎[1] 田立[1] 王仁杰 张亚超 王红 

机构地区：[1]中国人民解放军第467医院神经外科,050081 [2]北京军区高等医学专科学校实验中心

出　　处：《天津医药》1995年第7期411-413,共3页Tianjin Medical Journal

摘　　要：选用雄性Wistar大鼠86只,以落体致伤造成重型脑损伤模型。采用硫代巴比妥酸荧光比色法测定脑损伤后30mm、1h、3h、6h、12h、24h、48h、72h心、肝、肺、肾、胃中自由基代谢产物丙二醛(MDA)含量,并观察其病理变化,探讨脑损伤后自由基对心、肝、肺、肾、胃的损伤作用。结果表明:在脑损伤1h、3h、48h、12h、48h后,心、肝、肺、肾、胃中MDA含量与对照组比较明显升高(P<0.05),病理发现各脏器有不同程度损伤,揭示脑损伤后自由基不仅加重脑损伤,同时对脑以外脏器也具有损伤作用。Heavy brain injury models were made with the Allen' s weight-drop method in a group of 86 Wistar rats,malondialdehyde (MDA) content was measured with TBA technique in the other organs (including heart, liver, lung, kidney and stomach) after 30 min, l h, 3 h, 6 h, 12 h, 24 h, 48 h,and 72 h following the injury,at the same time,we also observed pathological changes of the organs. The resuits showed that MDA in the other organs rose obviously (P<0. 05)compared with the control group,and the other organ injuries in varying degrees were fourid.which meant that free radicals not only resulted in secondary hrain injury but also had harmful action on the other organs.

关 键 词：脑损伤 过氧化脂质 丙二醛 心脏 肝脏 肺 损害 

分 类 号：R651.150.2[医药卫生—外科学]