善得定对肝硬变患者门静脉系统血流动力学的影响  

The Effects of Sandostatin on Portal Hemodynamics of Hepatocirrhosis Patients

作　　者：王天才[1] 袁刚[1] 杨玉珍[1] 刘南植[1] 尹朝礼[1] 梁扩寰[1] 乐桂蓉[1] 张青萍[1] 

机构地区：[1]武汉同济医科大学附属同济医院

出　　处：《同济医科大学学报》1995年第1期43-45,共3页Acta Universitatis Medicinae Tongji

摘　　要：报道１５例肝硬变患者静脉给予善得定（Ｓａｎｄｏｓｔａｔｉｎ）后，采用彩色多普勒超声扫查门脉系统血流动力学变化。结果：除门脉右支（ＲＰＶ）和门脉左支（ＬＰＶ）的血管内径（Ｄ）和血流量（ＢＦ）用药前、后差异无显著性意义（Ｐ＞０．０５）外，门脉其它血管用药前、后Ｄ、ＢＦ和血流速度（ＴＡＶ）（包括ＲＰＶ和ＬＰＶ的ＴＡＶ）差异均有显著性意义（Ｐ＜０．０５或＜０．０１），同样，门脉压力（Ｐｐｖ）差异亦有显著性意义（Ｐ＜０．０１），即代偿期肝硬化Ｐｐｖ下降１６．９２％，失代偿期肝硬变Ｐｐｖ下降１２．６％。上述结果提示，Ｓａｎｄｏｓｔａｔｉｎ通过收缩腹腔内脏血管，降低血流量，使门脉压力下降而达到止血目的。patients with liver cirrhosis underwent color ultrasonography for hemodynamics in the portal vein system before and after intravenous injection of 0.1 mg of sandostatin. The result showed that the internal diameters and blood flow of right portal vein (RPV) and left portal vein (LPV) before and after medication showed no statisticalsignificance (P<0.05 or <0. 01).The internal diameters, blood flow and blood flow velocity(TAV)(including the velocity of RPV and LPV)of remaining portal system ,and the portal vein pressure revealed significant differences(P<0.01 ).The protal vein pressure decreased by 16.92% during compensating phase and by 12.0% during decompensating phase in liver cirrhosis patients. Our results demonstrated that sandostation achieved hemostasis by inducing the constriction of blood vessels of visceral organs and decreasing the volume of blood flow and the portal vein pressure.

关 键 词：善得定 肝硬变 食管静脉曲张 药物疗法 止血药 

分 类 号：R973.1[医药卫生—药品] R571.3[医药卫生—药学]