多巴酚丁胺对失血犬血流动力学的影响  

Effects of Debutamine on Hemodynamics in Hemorrhagic Dogs

作　　者：刘萍[1] 刘俊杰[1] 曾邦雄[1] 

机构地区：[1]武汉同济医科大学附属协和医院麻醉学教研室

出　　处：《同济医科大学学报》1995年第2期109-111,118,共4页Acta Universitatis Medicinae Tongji

摘　　要：为探讨多巴酚丁胺对血流动力学的影响，对６只失血犬进行了研究。实验分为３组，分别静注多巴酚丁胺５、１０和２０μｇ／ｋｇ。每次静注后２、５和１０ｍｉｎ测量并记录左心室压力、平均动脉压、动脉收缩压、动脉舒张压、中心静脉压和心排血量，然后计算心脏指数、心搏指数和全身血管阻力。静注多巴酚丁胺５μｇ／ｋｇ和１０μｇ／ｋｇ后２ｍｉｎ和５ｍｉｎ时，血流动力学指标显著升高。静注多巴酚丁胺２０μｇ／ｋｇ，血流动力学指标不仅２ｍｉｎ和５ｍｉｎ时变化有显著意义，而且１０ｍｉｎ时也产生有统计学意义的改变。Six hemorrhagic dogs were studied to explore the effects of dobutamine on hemodyamics.The animals were divided into three groups.Dogs in each group received dobutan1ine5、10 and 20 μg/kg respectively,LVP,MAP,SAP,DAP,CVP,CO,CI,SVI and SVR were measured,recorded and calculated after dog was injected dobutamine interavenously.Dobutamine 5 and 10μg/kg could markly increase most indices of hemodynamics in 2 and 5 min. Dobutamine 20 μg/kg not only significantly changed indices in 2 and 5 min,but also in 10 min.

关 键 词：多巴酚丁胺 血流动力学 休克 出血性 心血管药物 

分 类 号：R972.9[医药卫生—药品] R605.971[医药卫生—药学]