流行性出血热患者循环免疫复合物组份的动态观察  

Dynamic Changes of the Components Of Circulating Immune Complexes during Epidemic Hemorrhagic Fever Virus Infection

作　　者：郝连杰[1] 陈悦[1] 杨东亮[1] 喻植群[1] 李方和[1] 汪由坤[1] 刘立昆[1] 高学中[1] 杨颖潮[1] 李龙海 孟晓林 丁美琴 

机构地区：[1]武汉同济医科大学附属同济医院临床免疫研究室,安徽省阜阳地区出血热防治研究所

出　　处：《同济医科大学学报》1995年第4期261-263,共3页Acta Universitatis Medicinae Tongji

基　　金：国家自然科学基金

摘　　要：应用聚乙二醇沉淀法对２７例１１４份流行性出血热病人血清中循环免疫复合物（ＣＩＣ）进行了检测，不同病期（ＣＩＣ）检出率分别为：发热期８８．８％、少尿期８２．５％、多尿期４７．８％、恢复期２１．４％。对流行性出血热ＣＩＣ组份的动态观察发现，在不同病期ＣＩＣ中绝不多数可检出流行性出血热病毒抗原、免疫球蛋白与补体Ｃ３，表明在流行性出血热患者体内检出的ＣＩＣ是特异性病毒抗原刺激机体免疫应答的结果。ＩｇＧ、ＩｇＭ型ＣＩＣ的形成在疾病早期清除病毒抗原及免疫损伤中可能起重要作用。The circulating immune complexes(CIC)in the sera of patients suffering from epidemic hemorrhagic fever(EHF)were detected by using PEG precipitation assay.The detection rates of CIC in different phases of the disease are 88.8% in fever phase,82.5%in oliguric phase,47.8%in polyuric phase and 21.4%in convalescent phase,respectively.There were specific virus antigen,human Ig and C3 in the CIC precipitating during different phases of EHF virus infection,suggesting that the CIC in sera of patients were the products of immune response against EHF virus and may cause immunopathological injury by triggering complement system.The positive rates of IgG and IgM type CIG in earlier phase of the disease was higher than that in other phases and declined step by step with the improvement of the disease,showing that the formation of IgG and IgM type CIC may play an important role in clearing the virus antigen and inducing immunopathological injury during the earlier phase of the disease.

关 键 词：流行性出血热 循环免疫复合物 免疫球蛋白 

分 类 号：R512.803[医药卫生—内科学]