药瘾患者丙型肝炎病毒感染及其危险因素的血清学调查  

Serological Investigation of Hepatitis C Virus Infection and Risk Factors in Drug Abusers

作　　者：喻植群[1] 杨东亮[1] 赵西平[1] 李淋[1] 郝连杰[1] 顾秀华[1] 高连相[1] 

机构地区：[1]同济医科大学附属同济医院临床免疫学研究室,昆明医学院第一附属医院传染病学教研室

出　　处：《同济医科大学学报》1995年第5期330-332,共3页Acta Universitatis Medicinae Tongji

基　　金："国家"八.五"攻关项目

摘　　要：对４４１例药瘾患者血清乙型肝炎病毒（ＨＢＶ）及丙型肝炎病毒（ＨＣＶ）感染指标检测结果表明：ＨＢｓＡｇ检出率为８．６２％，ＨＢＶｍ检出率为８４．１３％，抗ＨＣＶ检出率为６０．５４％．不同性别患者间上述两种肝炎病毒感染率均无明显差别，但随着年龄增加，ＨＢＶ感染率逐渐上升，而抗ＨＣＶ检出率则逐渐下降．ＨＢＶ和ＨＣＶ感染率与药瘾途径有关，即口服者最低，静脉药瘾者次之，两者兼而有之者最高．对药瘾患者ＨＣＶ感染的危险因素分析表明，长期药瘾、静脉药瘾、共用注射器、使用未消毒药瘾用具及药品稀释液是主要的危险因素．Hepatitis B virus and hepatitis C virus infection marks in sera of 441 cases of drug abusers have been detected. The investigation result showed that the prevalence of HBsAg, HBV marks and anti-HCV were 8. 62%, 84. 13%and 60. 54%respectively. There were not significant difference in the infection rates of HBV and HCV between female and male drug abusers. The HBV infection rate was higher and HCV infection rate was lower in elder drug abusers than that in younger ones, We found that infection rates of HBV and HCV in drug abusers was closely related to routes of drug abuse,e.g. the highest was found in abusers who use drugs through both oral and intravenous routs, the lowest in abusers who use drugs orally only and the middle in abusers who use drugs intravenously only. Furthermore, analysis of the risk factors of HCV infection in drug abuser suggested that the main risk factors included persistent drug abuse, intravenous drug abuse, sharing syringe with others, using undisinfected syringes and drug diluent.

关 键 词：丙型肝炎病毒 乙型肝炎病毒 吸毒 血清诊断 

分 类 号：R512.630.4[医药卫生—内科学] R373.21[医药卫生—临床医学]