国产和美国产乙型肝炎血源疫苗五年效果比较  

A 5-years Follow-up of Newborns Vaccinated against Hepatitis B

作　　者：李雪翔[1] 谢广中[1] 张谋鸿 孙景明[1] 肖亮明[1] 姚福宝[1] 叶和清[1] 杜玉霞[1] 张绍美[1] 

机构地区：[1]卫生部上海生物制品研究所,江苏省徐州医学院附属医院

出　　处：《微生物学免疫学进展》1995年第1期31-33,共3页Progress In Microbiology and Immunology

摘　　要：母亲ＨＢｓＡｇ和ＨＢｅＡｇ均阳性者所生之婴儿，随机接种国产和美国产乙肝疫苗，免疫后５年婴儿ＨＢｓＡｇ携带率分别为１５．４％和１８．２％；抗－ＨＢｓ，阳性率各为７６．９％和７７．３％，两组均无显著性差别。39 infants born from hepatitis B surface antigen (HBsAg) and hepatitis B e antigen (HBeAg) positive mothers were included in this study. 5 of 16 recipients who received Merck vaccine(group M) and 5 of 23 recipients who received Shanghai vaccine (group N) were converted to HBsAg positive at 12 months of age.Five years after vaccination the infants for HBsAg positive in groups M and N were 15. 5% (2/13)and 18.2% (4/22) (p=0. 138), respectively, In the groups M and N percentages of infants with anti-HBs＞10mIU/ml were 73. 3% and 77. 3% (p= 0. 29)、76. 9% and 77. 3% (p=0. 323) at 3 and 5 years, respectively. Anti-HBs titres were 50. 2 and 50.5mIU/ml (p＞0. 05) , 28. 7 and 23. 8mIU/ml (t=0. 28, p＞0. 05)at 3 and 5 years, respectively. The results Showed that there is no significant difference in five years protection between two vaccines.

关 键 词：随访 五年随访 免疫应答 乙型肝炎疫苗 

分 类 号：R512.620.3[医药卫生—内科学]