东莨菪碱合剂对大白鼠早期急性DIC的治疗作用  

Therapeutic Effect of Mixture Scopolamine on Rats within Early Stage of Acute Disseminated Intravascular Coagulation

作　　者：李时宜[1] 

机构地区：[1]广东省汕头大学医学院儿科教研室

出　　处：《微循环学杂志》1995年第4期8-10,共3页Chinese Journal of Microcirculation

摘　　要：采用高分子右旋醣酐加少许钙剂在３７只Ｗｉｓｔａｒ雄性健康大白鼠中塑造急性ＤＩＣ模型，用东莨菪碱合剂实验治疗。以微循环监测、血片裂体细胞数、血小板计数、血红蛋白含量及血气分析作为检查指标。实验分三组：扩容加莨菪组（１０只大鼠）；扩容组（７只大鼠）；未治疗组（２０只大鼠）。结果于早期急性ＤＩＣ用扩容加莨菪组治疗的１０只鼠，存活２日的共３只，存活３日以上的共７只；扩容组７只鼠均于实验第２日内死亡。未治疗组２０只鼠，造病后３～２４ｈ内相继死亡。提示：采用纠酸扩容基础上加用东莨菪碱合剂，可以及早中断早期急性ＤＩＣ的发展，从而使ＤＩＣ的预后得到改观。Observations on the curative effect of a Scopolamine mixture were performed on 37 Wistar male rats.They were injected(Ⅳ)with 10% high molecular weight Dextran and 5% calcium gluconas to produce acute disseminateal intravascular coagulation(DIC).When the early stage of acute DIC appeared in 17 ran,they were given rehydration therapy and were divided into two groups. In the lst group,10 rats were treated with expansion of blood volume and adding the mixture of Scopolamine.The 2nd group was only treated with expansion of blood volume.The control group,20 rats,received no therapy.The results showed that remarkable effects on physical examination and the microcirculationwere observed in the lst group.Three rats stayed alive for 2 days and the other 7 rats stayed alive over 3 days.In the 2nd group,all 7 rats were always cyanotic and dyspneic.Their microcirculation of the cremaster muscle was abnormal.They died within 2 days.In the control trol group,all 20 rats developed severe bleeding and died within 3～24 hours.On histological examination,a few hyaline thrombi were found in the capillaries of the lungs of some rats.It illustrates that mixture Scopolamine can interrupt the development of acute DIC in early stage by correcting the water and electrolyte balance and improving the microcirculation.So,the prognosis is much more favorable.

关 键 词：播散性 血管内凝血 东莨菪碱 合剂 大白鼠 DIC 

分 类 号：R554.8[医药卫生—血液循环系统疾病]