脂质过氧化与抗氧化在肾小球疾病中的研究  

Research on lipid peroxidation and antioxidation in glomerular diseases

作　　者：高月清[1] 阎祝三[1] 孙波[1] 金亚平[1] 

机构地区：[1]山东烟台毓璜顶医院肾内科,中国医科大学卫生系,中国医科大学第一临床学院

出　　处：《卫生研究》1995年第6期368-370,共3页Journal of Hygiene Research

摘　　要：本研究测定了２５例原发性肾病综合症（ＰＮＳ），１５例急性肾小球肾炎（ＡＧＮ）患者和３０例健康人血清脂质过氧化物（ＬＰＯ）、全血超氧化物歧化酶（ＳＯＤ）和全血谷胱甘肽过氧化物酶（ＧＳＨ－Ｐｘ）的含量。结果：ＰＮＳ组和ＡＧＮ组血清ＬＰＯ均显著高于对照组（Ｐ＜０．０１）；ＰＮＳ组和ＡＧＮ组全血ＳＯＤ均显著低于对照组（Ｐ＜０．０５）；ＰＮＳ组和ＡＧＮ组全血（ＧＳＨ－Ｐｘ）与对照组相比，均无显著性差异（Ｐ＞０．０５）。表明ＰＮＳ和ＡＧＮ患者脂质过氧化作用增强，抗氧化机能下降，提示ＰＮＳ和ＡＧＮ的发生与脂质过氧化和抗氧化机能失衡有关。The contents of serum lipid peroxides(LPO),blood superoxide dismutase (SOD) and blood glutathione peroxidase(GSH-Px) were measured in 25 patients with primary nephrotic syndrome ( PNS) ,15 patients with acute glomerulonephritis( AGN) and 30 normal subjects. The results indicate that the content of LPO was significantly higher in PNS and AGN groups than in the control group( P<0.01) . The content of SOD was significantly lower in PNS and AGN groups than in the control group( P<0. 05) . The contents of GSHPX in the PNS and AGN groups were not statistically different from that in the control groups ( P > 0.05) . In conclusion , the contents of LPO in PNS and AGN groups elevated. It suggests that the pathogenesis of PNS and AGN relates to the unbalance of lipid peroxidation and antioxidant function. (Yantai Yuhuangding Hospital ,Shandong Provience,264000China)(Dept.of Hygiene ,China Medical University)

关 键 词：肾小球疾病 脂质过氧化 抗氧化 

分 类 号：R692.602[医药卫生—泌尿科学]