溴氰菊酯对大鼠肝线粒体、微粒体钙离子转运的影响  

Effect of decamethrin on calcium transport of mitochondria and microsome in rat liver

作　　者：张秀莲[1] 夹访贤[1] 于丽华[1] 菅向东[1] 

机构地区：[1]山东医科大学毒理学研究室

出　　处：《卫生研究》1995年第2期68-71,共4页Journal of Hygiene Research

基　　金：卫生部中青年自然科学基金

摘　　要：采用体外放射性同位素测定技术，观察了溴氰菊酯对雄性大鼠肝线粒体、微粒体钙离子转运的影响，结果表明溴氰菊酯能明显降低大鼠肝线粒体、微粒体４５Ｃａ主动摄取的能力，与对照组相比均具有非常显著性差异（Ｐ＜０．０１），且存在明显的剂量效应关系。而溴氰菊酯对大鼠肝线粒体、微粒体４５Ｃａ被动释放的动力学表明，它可显著增加４５Ｃａ从线粒体、微粒体内的被动流出，与对照组相比差异均显著（Ｐ＜０．０５或ｐ＜０．０１），且有明显的剂量效应关系。另外，溴氰菊酯还能明显抑制大鼠肝线粒体、微粒体Ｃａ２＋－ＡＴＰ酶的活力，与对照组相比差异均显著（Ｐ＜０．０５或Ｐ＜０．０１），也存在明显的剂量效应关系。Radioactive isotope technique in vitro was used to observe the effect of decamethrin on calcium transport in rat liver mitochondria and microsome.The results indicated that decamethrin could decrease the ability of45 Ca uptake by mitochondria and microsome(P<0.01,compared with control group) on a dose-effect relation.Decamethrin could increase45 Ca released from mitochondria and microsome(P<0.05 or P<0.01,compared with control group).Dose-effect relation and time-effect relation were also noticed.The activity of Ca-atpase was also inhibited(P<0.05 or P<0.01,compared with control group) on dose-effect relation.

关 键 词：溴氰菊酯 线粒体 钙 大鼠 

分 类 号：R994.3[医药卫生—毒理学]