氰戊菊酯神经毒性的电生理生化和形态学研究  

Electrophysiological-biochemical and morphological studies on the neurotoxicity of fenvalerate in rats and mice

作　　者：陈寅虹 殷若元[1] 高玉平[1] 任春兰[1] 

机构地区：[1]镇江医学院劳动卫生教研室,南京农业大学

出　　处：《卫生研究》1995年第3期129-131,共3页Journal of Hygiene Research

基　　金：江苏省自然科学基金

摘　　要：氰戊菊酯（Ｆｅｎ）可明显降低大鼠坐骨神经传导潜速率，并对大鼠股外侧肌电图的轻、重收缩波波幅降低，轻收缩波的时限可有所延长；Ｆｅｎ可使ＭＤＡ、ＧＳＳＧ升高，ＧＳＨ下降，说明Ｆｅｎ对神经细胞膜的脂质成分有一定的氧化毒性；Ｆｅｎ还可使神经细胞膜完整性破坏，胞体和线粒体肿胀；神经髓鞘结构模糊和板层的可分离性裂隙增大。The authors studied the neurotoxicity of fenvalerate(Fen) in rat and mouse nerve cells with eicctroPhysiology, biochemistry and electron microscopy techniques. The electrophysiological results showed that motor conduction latency rate of rat sciatic nerve was reduced significantly by Fen at the dosages of 40, 80 and 120mg/kg(bw). The amplitude of electromyogram(EMG)in gentle contraction of the vastus leteralis was diminished with the duration prolonged.Amplitude of EMG in heavy contraction was diminished as well.The contents of GSSG and MDA increased, whereas the content of GSH was reduced by Fen at respective dosages(40, 80 and 120mg/kg). These neurobiochemical results indicate that Fen enhanced some oxidative toxicity to lipid in nerve cell membranes which provides biochemical basis for the effect of Fen on electrophysiology.The electron microscope results showed that morphological changes caused by Fen in rat cerebellum cells included swelling of nerve cell body and mitochondrium, and damage of com pleteness of nerve cell membrane. Nyelin sheath structure was obscuritied and separable crack of sheath plate was enlarged.

关 键 词：氰戊菊脂 神经电生理 脂质过氧化 

分 类 号：R139.3[医药卫生—劳动卫生]