注射丈夫的淋巴细胞治疗原因不明的流产  

Treatment of Female Patients with Unexplained Miscarriage by Injecting the lymphocytes of Their Husbands

作　　者：张世训 史兆永 司桂玲 郭宗琴[1] 伊林[1] 李京[1] 陈延琴[2] 王佩贞[2] 

机构地区：[1]山东省血液中心 [2]山东省立医院

出　　处：《中国输血杂志》1989年第4期169-171,共3页Chinese Journal of Blood Transfusion

摘　　要：本文报道治疗原因不明流产的一种新方法.接受治疗的32例中,28例(87.5%)妊娠成功;对照组35例,9例妊娠成功.两组比较,有显著性差异(P<0.01).对22例接受治疗的妇女血清进行了HLA-DR抗体检测,治疗前均为阴性,治疗后12例(54.5%)阳性,妊娠期14例(63.6%)阳性.9对夫妇HLA分型.仅2对夫妇有1个DR位点相同的抗原.检测7例免疫后的妇女血清,其中4例有针对丈夫HLA特异性抗体的抗个体基因型抗体.The paper showed that the female patients with unexplained miscarriage can be treated by injecting the lymphocytes of their husbands. Twenty-eight of 32 tested cases had had successful conception(87.5%) as compared with 9 of 35 control cases (25.7%). The difference between two groups was significant (P<0.01). The test of sera for HLA-DR antibodies in 22 tested patients was as follows: negative In all of them before the treatment; positive in 12 of them (54.5%) after the treatment and positive in 14 of them (63.6%) during gestational period. In HLA typing, only 2 of 9 couples shared the same antigen at one HLA-DR locus. The test of immunized sera for anti-idiotypic antibodies in 5 tested patients indicated that 4 of them developed anti-idiotypic antibodies against the specific antibodies of their husbands

关 键 词：流产 淋巴细胞 配偶 

分 类 号：R714.21[医药卫生—妇产科学]