EA花环抑制试验检测反复自然流产患者血清中的Fc受体封闭抗体  

Detection of Fc receptor blocking antibodies by erythrocyte-antibedy rosette in serum of patients with recurrent spontaneous abortion

作　　者：程鲁京[1] 王艾丽[1] 武建国[1] 陆康民[1] 党洁民[1] 

机构地区：[1]解放军南京军区总医院

出　　处：《武警医学》1995年第5期259-261,共3页Medical Journal of the Chinese People's Armed Police Force

摘　　要：用致敏牛红细胞（ＯＲＢＣ）建立ＥＡ花环抑制（ＥＡＩ）试验，检测了原发性、继发性反复自然流产（ＲＳＡ）患者，正常妊娠、正常已生育和未婚女性血清中的Ｆｃ受体封闭抗体（ＦｃＲ－Ｂａｂ）。结果：原发性ＲＳＡ为７．８３±８．９７％，继发性ＲＳＡ为３５．４７％±２７．４８％，正常妊娠为４２．１０±１４．２１％。正常已生育为４１．９３±２１．５４％。原发性ＲＳＡ患者ＦｃＲ－Ｂａｂ显著低于其他组（Ｐ＜０．０１），与未婚女性组近似（Ｐ＞０．０５）。而常规检测封闭抗体的抗夫淋巴细胞毒试验结果，在各组间未见显著差异（Ｐ＞０．０５）。表明此法可作为对原发性ＲＳＡ的诊断、治疗和疗效观察的一项有意义指标。Fc receptor blocking antibodies (FcR -Bab) were detected by erythrocyte-antibodyrosette inhibition assay (EAI)in serum of patients with primary and secondary recurrent spontaneous abortion(FcR),normal pregnant, multiparous and unmarried women. FcR-Bab was positive in 7. 83±8. 79%, 35. 47±27. 48%, 42. 10±14. 21 %,and 41. 93±21. 54%of primary RSA group, secondary RSA group, normal level pregnant and normal parous women,respectively. FcR- Bab in the primary RSA group was lower than that in the other groups (P<0. 01),but it was similar to that in the unmarried group(P>0. 05). It is indicated that this test can serve as a significant index for diagnosis and observation of therapeutic effect of primary RSA.

关 键 词：反复自然流产 EA花环抑制试验 Fc受体封闭抗体 

分 类 号：R714.21[医药卫生—妇产科学]