缺Zn大鼠海马神经元内Zn变化的形态计量学研究  

Effect of zinc deficiency on zinc metabolism in rat hippocampal neurons

作　　者：李积胜[1] 徐鹏霄[1] 邓昌辉[1] 

机构地区：[1]武警医学院解剖教研室

出　　处：《武警医学》1995年第6期311-313,共3页Medical Journal of the Chinese People's Armed Police Force

摘　　要：采用Ｔｉｍｍ氏硫化银法及图象分析法，对单纯缺Ｚｎ大鼠海马细胞内Ｚｎ灰度值的变化进行了研究。结果表明：在缺Ｚｎ状态下，海马ＣＡ１、ＣＡ３齿状回和ＣＡ４区的光密度均降低（Ｐ＜０．０５）。提示：缺Ｚｎ早期，脑海马神经细胞内可螯合Ｚｎ的减少，超前于海马Ｚｎ总浓度的变化。Changes in zinc grey values in the hippocampal neurons of zinc-deficient rats were observed by Timm's histochemical method and quantitive graphic analysis. The results showed that the grey values of CA1,CA3,dentate gyrus and the optical density of CA4 area were lower than those in the non-deficient group. It is suggested that the chelatable zinc in the hippocampus decreases before the change in total zinc change in hiffocampus.

关 键 词：锌缺乏 海马 神经元 锌 形态计量学 

分 类 号：R591.102[医药卫生—内科学]