氯胍对大鼠主动脉条收缩反应及豚鼠乳头状肌和兔窦房结动作电位的影响  

Effects of chloroguanide on contraction ofrat aortic strips and action potential in guineapig papillary muscles and rabbit sinoatrial nodes

作　　者：李迪民[1] 毛新明[1] 王雪飞[1] 王晓雯[1] 周承明[1] 张克锦[1] 

机构地区：[1]新疆医学院药理教研室

出　　处：《西北药学杂志》1995年第6期254-257,共4页Northwest Pharmaceutical Journal

摘　　要：氯胍抑制氯化钾、去甲肾上腺素和氯化钙引起的大鼠主动脉条收缩反应。ＰＤ－２值分别为３．６４±０．２６，４．２５±０．４５和４．８５±０．９９；氯胍可使豚鼠乳头状肌细胞动作电位Ｖｍａｘ下降，ＡＰＤ２５和ＡＰＤ３５缩短，兔窦房结细胞动作电位Ｖｍａｘ下降，４相自发除极斜率下降，高Ｋ＋部分除极的豚鼠乳头状肌细胞慢反应动作电位的Ｖｍａｘ下降。结果提示：氯胍具有抑制钙通道和钠通道的作用。Chloroguanide (CG) inhibited the contraction induced by KCI, CaCl2,and norepinephrine(NE). The PD-2, Values were 3. 92±0. 26, 4. 39±0. 26 and 4. 26± 0.18 respectively; CG made Vmax lower and shortened APD25 and APD35 of action potetialsin guinea pig papillary muscls. CG decreased Vmax and slope of phase 4 of action potentialin rabbit sinoatrial nodes. The results suggested that CG had inhibited effects on Na+ andCa2+ channel.

关 键 词：氯胍 心肌收缩 动作电位 大鼠 窦房结 

分 类 号：R965.2[医药卫生—药理学]