大鼠矽肺支气管肺泡灌洗液和肺组织磷脂谱的研究  

STUDY OF CONTENTS OF PHOSPHOLIPIDS IN THE BRONCHOALVEOLAR LAVAGE FLUID AND LUNG TISSUE OF SILICOTIC RATS

作　　者：杨青[1] 

机构地区：[1]华西医科大学尘肺研究室

出　　处：《现代预防医学》1995年第2期65-67,共3页Modern Preventive Medicine

摘　　要：本文报告了大鼠矽肺支气管肺泡灌洗液和肺组织磷脂谱间变化的关系。实验分为正常对照组和石英组，在染尘后１５、４５、９０、１８０和２７０天分批剖检，测定其灌洗液和肺组织中总磷脂、ＤＰＰＣ、ＰＧ、ＰＥ含量。结果表明在实验期间石英组灌洗液和肺组织中总磷脂、ＤＰＰＣ、ＰＧ和ＰＥ含量呈升高趋势，且早期变化明显，但二者并不是呈简单的对应关系。推测影响灌洗液和肺组织磷脂谱含量和比值变化的因素有所不同。In this study the relationship of contents of phospholipids in the bronchoalveolar lavage fluid(BALF) and lung tissue of silicotic rats was reported. The experimental rats include control group and silicosis group. All rats were killed at an interval of 15,45,90,180 and 270 days. The contents of total phospholipid, dipalmitoylphosphatidylcholine(DPPC), phosphatidylglycerol ( PG ) and phosphatidylethanolamine(PE) were measured. The results showed that the content of phospholipid,DPPC, PG and PE in the BALF and lung tissue of silicosis group was higher than that of the control group,special in the early period,but the relationship between the BALF and lung tissue was no simple partner.These results suggested that the factors effecting the content and rate of phospholipids in the BALF and lung tissue were different.

关 键 词：矽肺 磷脂 肺灌洗液 病理 

分 类 号：R598.2[医药卫生—内科学]