围产期窒息新生儿血浆内皮素的变化  

CHANGES OF PLASMA ENDOTHELIN IN NEWBORNS WITH PERINATAL ASPHYXIA

作　　者：冯建华[1] 洪文澜[1] 康曼丽[1] 徐勤[2] 郁金声[2] 

机构地区：[1]浙江医科大学附属儿童医院内科,310003 [2]浙江医科大学附属儿童医院核医学科

出　　处：《新生儿科杂志》1995年第6期250-252,共3页The Journal of Neonatology

摘　　要：应用放射免疫分析法观察34例围产期窒息新生儿血浆内成素（ET－1）的动态变化，其中轻度窒息19列，重度窒息15例，9例合并颅内出血，并与33例正常新生儿进行对照。结果表明窒息组血浆ET－1测定值高于对照组，重度窒息组显著高于轻度窒息组，9例合并颅内出血患儿血浆ET－1升高更为显著，经过复苏及治疗后ET－1渐下降至正常水平。提示内皮素参与围产期窒息的病理生理过程，并与窒息的严重程度有关。Dynamic variances of plasma endothelin-1 (ET-1) in 34 cases with perinatal asphyxia were .observed by radioimmunoassay. Among them 19 were mild asphyxia, 15 were severe, 9 were complicated intracerebral hemorrhage. 33 normal newborns were as control group. The results showed that the determinations of plasrpa ET-1 in asphyxia group was higher than that in control group. The severe asphyxia group was significantly higher than the mild. 9 cases complicated intracerebral hemorrhage showed plasma ET-1 matkedly increased. With the resuscitation and treatment, the levels of plasma ET-1 decreased gradually to normal level. This suggested that endothelin may play a role in the pathophysiology of neonatal asphyxia and may have some relation to the severity of asphyxia.

关 键 词：围产期窒息 新生儿 血浆 内皮素 

分 类 号：R722.12[医药卫生—儿科]