蝮蛇抗栓酶对高粘血症病人的血液流变学和甲襞微循环的影响  

Influences of Fu-she-kang-shuan-mei on hemorheology and hyponychial microcirculation of patients with hyperhemoviscositosis

作　　者：苏林青[1] 丁世芳[1] 马大波[1] 王淑君[1] 孙洁[1] 田眼亮 

机构地区：[1]中国人民解放军广州军区武汉总医院

出　　处：《新药与临床》1995年第2期83-85,共3页

摘　　要：２１０例高粘血症病人（男性１４６例，女性６４例；年龄６２±ｓ８ａ）．经用蝮蛇抗栓酶１．０Ｕ加１０％葡萄糖液２５０ｍＬ，静脉滴注。１次／ｄ，１５ｄ为一个疗程。观察治疗前后全部病人的血液流变学和６０例甲襞微循环的变化，结果：治疗后凝血因子Ⅰ、全血比粘度、血浆比粘度均显著下降（Ｐ＜０．０１）。甲襞微循环也显示：淤血及红细胞聚集缓解，血流态异常好转，血流速加快，微循环明显改善。Patients(M146,F64;age 62± s 8 a) with hyperhemoviscositosis were treated with Fu-she-kang-shuan-mei 1 U diluted in 10% glucose 250 mL,iv,gtt,qd,for 15 d.Before and after treatment the hemorheology of all patients and hyponychial microcirculation of 60 patients were observed.The results showed that after the usage of Fu-she-kang-shuan-mei fibrinogen level decreased remarkably(t test,P<0.01).Whole blood viscosity,high shear rate,low shear rate and serum relative viscosity lowered(P<0.01).Hyponychial microcirculation also presented that passive congestion and red blood cell aggregation were alleviated, the blood flow state abnormality was improved,blood velocity increased.The hyponychial microcirculation became into better condition.

关 键 词：蝮蛇抗栓酶 蛇毒类 高粘血症 血液粘度 微循环 

分 类 号：R552.05[医药卫生—血液循环系统疾病]