真丝人造血管移植后愈合过程的病理学研究  

PATHOLOGIC STUDY OF THE HEALING PROCESS OF PURE SILK VASCULAR PROSTHESIS AFTER IMPLANTATION

作　　者：黄士通[1] 陈灏珠[1] 费绍华 冯友贤 李建明 郑佳瑾[2] 

机构地区：[1]上海市心血管病研究所 [2]上海医科大学中山医院

出　　处：《中国循环杂志》1989年第1期49-50,共2页Chinese Circulation Journal

摘　　要：对30条犬的胸主动脉或腹主动脉移植一段真丝人造血管后24小时～13个月,分期处死,进行病理形态学观察。结果显示,人造血管的管腔面内衬内皮和平滑肌两种细胞。本文对上述两种细胞的来源、形态特点以及人造血管的新内、外膜形成过程等方面进行了讨论。Huang Shi-tong, Feng You-xian, et al. Cardiovascular Institute and Zhong Shan Hospital, Shanghai Medical University, ShanghaiThe healing process of pure silk prosthesis was observed after the implantation to thoracic or abdominal aorta in 30 dogs. The duration of observation lasted from 24 hours to 13 months. Several days after the implantation, the prosthesis was lined by a thin layer of fibrin. One week later, a layer of new adventitia was formed. One month after-ward, a layer of neointima mainly composed of smooth muscle cells could be soon. Three months later, the neointima was covered by endothelial cells. The prosthesis was sand-wiched between the new intima and adventitia. After 8～13 months, the graft had a thin smooth greyish white neointima, which was lined by endothelial cells or smooth muscle cells. These cells originated from the endothelial and smooth muscle cells of the host's vessel respectively. There was marked fibrous hyperplasia in the new intima and adventitia of the prothesis. The silk itself did not show any noticeable change. Study of the healing process of the prothetic vessel leads us to understand the nature and tissue reaction of the prothesis.

关 键 词：人造血管 新内膜 移植术 

分 类 号：R318.11[医药卫生—生物医学工程]