心律失常患者血清可溶性白细胞介素－2受体的变化及意义初探  

The Changes of Serum Soluble Interleukin-2 Receptor in Patients With Arrhythmia and Its Significance

作　　者：许金成[1] 王淑斐[1] 陈群[1] 

机构地区：[1]广东医学院附属医院,广东医学院微生物学教研室

出　　处：《心脏起搏与心电生理杂志》1995年第2期73-74,共2页

摘　　要：应用酶标双抗体夹心法（ＥＬＩＳＡ）测定３０例心律失常患者（其中心房颤动１２例、室性早搏９例、房性早搏９例）血清可溶性白细胞介素－２受体（ＳＩＬ－２Ｒ）的水平。以３２例不伴心律失常的心脏病患者作对照，并与３０例正常人作比较。三组血清ＳＩＬ－２Ｒ水平分别为３７０．１±１８１．８，１８４．５±９６．５，７９．１±２７．４ｕ／ｍｌ，心律失常组高于对照组和正常组（Ｐ均＜０．００１）；对照组ＳＩＬ－２Ｒ水平亦高于正常组（Ｐ＜０．００１）；不同类型心律失常患者的血清ＳＩＬ－２Ｒ水平比较差异无显著性（Ｐ＞０．０５）。提示心律失常患者可能存在免疫功能紊乱；ＳＩＬ－２Ｒ可作为衡量心律失常患者的细胞免疫活性的一个指标。The serum soluble interleukin-2 receptor(SIL-2R) in 30 patients with arrhythmias(12 cases of atrial fibrillation, 9 cases of ventricular premature heats and 9 cases of atrial premature beats) was determined by enzyme linked immune sandwith assay(ELISA)technique 32 patients with cardiovascular disease without arrhythmias and 30 normal persons were as control. The results showed that the level of SIL-2R in patients with arrhythmia was higher than the controls(370.1±181.8 VS 184.5±96.5,79.1±27. 4 u/ml,P<0.001),and there was no statistical significance in the different types of arrhythmia( P>0.05). It suggested that the patients with arrhythmias might have immunologic function disorder, and SIL-2R might a indicator for assessing the cellular immunity function of some kinds of arrhythmias.

关 键 词：心律失常 白细胞介素2 受体 

分 类 号：R541.703[医药卫生—心血管疾病]