高三尖杉酯碱和青光眼滤过性手术的实验研究  

An Experimental Study on Homoharringtonine and Glaucoma Surgery

作　　者：彭大伟[1] 田祥[2] 曾淑君[3] 余克明[1] 郑桂英 张洁[1] 

机构地区：[1]中山医科大学中山眼科中心,广州510060 [2]遵义医学院眼科 [3]中山医科大学药理教研室

出　　处：《眼科学报》1995年第2期76-79,共4页Eye Science

摘　　要：目的:观察中药高三尖杉酯碱对滤过道伤口愈合过程的抑制作用。方法:用20只家兔制成抗青光眼滤过性手术模型(后唇巩膜咬切术),采用随机对照法,每只兔的一眼结膜下注射高三尖杉酯碱,另一眼注射生理盐水。结果:术后十四天,实验眼的眼压下降比对照组明显(P<0.05),滤过泡的存留数也明显多(14/6),病理组织学检查见实验眼滤过道单位面积的成纤维细胞数比对照组少(P<0.01),未见严重和持久的眼部毒副作用。结论:本研究提示高三尖杉酯碱能明显抑制青光眼滤过性手术后滤过道的瘢痕化,促进滤过泡的形成,为今后的临床应用提供了有力的依据。眼科学报 1995;11:76—79。Purpose : To test the inhibiting effect of a Chinese herbal drug, Homoharring-tonine (HH) on the wound healing process at the filtering site in an experimental model.Methods: Posterior sclerectomies were performed in 20 rabbits. Postoperatively one eye of each rabbit received subconjunctival injections of HH and fellow eye received saline injections in a randomized masked fashion.Results:14 days after operation, intraocular pressure decreased significantly compared with that of control (P<0. 05). The number of filtration blebs was greater than that of control (14/6). On pathological examination, the number of fibrob-lasts per square measure of cross section of tissue cut from filtration region that was diminished significantly compared with that of control (P<0. 01). There were no serious and permanent ocular toxic and side effects.Conclusions : The study suggests that the HH can inhibit cicatrization at the glaucoma filtering site, promote the formation of filtering blebs and provide a sufficient edence for the further clinical use of HH. Eye Science 1995; 11: 76 -79.

关 键 词：高三尖杉酯碱 青光眼 滤过性手术 治疗应用 

分 类 号：R979.1[医药卫生—药品] R779.6[医药卫生—药学]