三唑仑药物的固相萃取和气相色谱法的研究  

The Method for Determination of Triazolam Using Solid Phase Extraction and GC/NPD

作　　者：孙静 何毅 

机构地区：[1]北京公安部第二研究所

出　　处：《药物分析杂志》1995年第6期11-13,共3页Chinese Journal of Pharmaceutical Analysis

摘　　要：本文建立了新型安眠镇静药三唑仑的气相色谱分析方法。采用固相柱ＧＤＸ４０３提取净化，ＧＣ／ＮＰＤ法分析送检样品中的三唑仑，并用ＳＫＦ＿（５２５Ａ）作为内标进行质量控制。进行了茶水中添加三唑仑的实验研究，确立了提取净化的最佳ｐＨ值范围和提取溶剂（淋洗剂）。结果表明，该方法灵敏度高，最小检测量小于５ｎｇ，２０ｍｌ茶水中添加１０μｇ三唑仑的回收率大于７０％。并报道了几例案例的应用情况。The solid phase extraction(SPE)method was developed for the analysis of triazolam. The procedure was carried out by using GDX 403 column and SKF525A was used as the internal standard,suspected samples of containing triazolam,such as tea water,beer etc,were purified by a SPE column. The extract is analysed by GC/NPD。 The procedure is presently being used in case work and the results from 4 cases were presented.

关 键 词：三唑仑 固相萃取技术 GC/NPD 

分 类 号：R927[医药卫生—药学]