5－乙基－5－对氟苯甲酰丙基巴比妥酸在兔体内的代谢产物研究  

STUDY ON METABOLITE OF 5-ETHYL-5-(PARA-FLUOROBENZOYLPROPYL)BARBITURIC ACID IN RABBITS

作　　者：富戈[1] 董善年[1] 孙守威 马亚萍 

机构地区：[1]北京医科大学药学院,国家标准物质研究所质谱室

出　　处：《药学学报》1995年第8期610-614,共5页Acta Pharmaceutica Sinica

摘　　要：用高效液相色谱法对５－乙基－５－对氟苯甲酰丙基巴比妥酸在家兔体内的代谢物进行了分离，用二极管阵列检测器测定了原药及代谢物紫外图谱，得出代谢物的紫外吸收性质；同时测试了原药及代谢物的质谱，推测出代谢物的可能结构，并用化学方法合成了代谢物对照品，通过核磁和质谱的测定进一步确证了结构。The metabolite of 5-ethyl-5-( p-fluorobenzoylpropy)harbituric acid(coded asF-B-1) in rabbit has been separated with HPLC. UV-spectra of F-B-1 and its metabolite obtained withDAD, in combination with EI-MS and CI-MS of F-B-1, its metabolite and their derivatives wereexamined. Possible structure of the metabolite was obtained.Possible metabolic way of F-B-1 is thereduction of carbonyl on the benzene ring with formation of hydroxyl group. This was furtherconfirmed by identity of HPLC and MS behavior of the metabolite and NaBH4 reductive preduct. Inthe structure of the latter, the carbonyl on the benzene ring was reduced, as proved by NMR(lH-NMR and 13C-NMR)spectra.

关 键 词：巴比妥酸 代谢物 高效液相色谱 尿药浓度 

分 类 号：R969.1[医药卫生—药理学] R971.3[医药卫生—药学]