固相萃取─紫外导数光谱法　测定生物检材中安眠酮含量  

The Determination of Methaqualonum in Biological Samples by Solid-phase Extraction and Derivative UV Spectrophotometry

作　　者：谭家镒[1] 吴玉红[1] 姜兆林[1] 

机构地区：[1]中国刑警学院法化系

出　　处：《药物分析杂志》1995年第2期21-23,共3页Chinese Journal of Pharmaceutical Analysis

摘　　要：本文报道血、尿、肝、肾、肺、脑等检材中安眠酮含量的固相萃取－紫外导数光谱测定法。该法操作简便，检出限在０．５μｇ／ｇ（或０．５μｇ／ｍｌ）以下。每１ｇ或１ｍｌ检材中加入药物１０μｇ进行测定，各种检材平均回收率均在８０％以上，相对标准偏差均在５％以下。该法适于做为法医毒物分析的常规方法。A simple and rapid method for the determination of Methaqualonum in organ tissues and body fluid is deseribed in this paper. The procedure involves solid- phase extraction using GDX403 or X5 porous polymeric sorbent made in China and derivative UV spectrophotometry. Limits of detection of Methaqualonum in specimens using this method are bellow 0. 5μg/g or 0.5μg/ml.The average recoveries of Methaqualonum are more than 80% and the relative standard deviation of recoveries are less than 5%for five replicate determinations of 10μg of Methaqualonum added to one gram of specimen.

关 键 词：安眠酮 生物检材 固相萃取 紫外导数光谱法 

分 类 号：R991[医药卫生—毒理学]