粉防己碱对DOCA盐性高血压心肌肥厚大鼠心脏血流动力学的影响  

EFFECTS OF TETRANDRINE ON CARDIAC HEMODYNAMICS OF HYPERTROPHIED LEFT VENTRICLE FROM DEOXYCORTIICOSTERONE-SALT HYPERTENSIVE RATS

作　　者：徐毅[1] 饶曼人[1] 

机构地区：[1]南京医科大学心血管药理研究室,湖南医科大学心血管生理研究室

出　　处：《药学学报》1995年第2期86-92,共7页Acta Pharmaceutica Sinica

基　　金：国家自然科学基金

摘　　要：粉防己碱可显著降低ＤＯＣＡ盐性高血压心肌肥厚大鼠的血压，左室湿重；在工作心脏研究中发现其改善肥厚心室的收缩（ＡＰ，ＬＶＳＰ，＋ｄｐ／ｄｔｍａｘ）舒张（一ｄｐ／ｄｔａｍｘ，ＬＶＥＤＰ，Ｔ值）性能，尤以舒张性能改善明显，并恢复泵功能（ＣＯ）和冠脉流量（ＣＦ）；在左室压力容积关系法研究显示有改善肥厚心室左室顺应性和左室僵硬度的作用。提示：Ｔｅｔ有逆转心肌肥厚和改善肥厚心肌舒张收缩功能，左室顺应性和心肌劲度的作用。Effects of tetrandrine(Tet)on cardiac mass and hemodynamic parameters were studied in deoxycorticosterone-salt(DOCA-salt )hypertensive rats. Treatment with Tet(50mg·kg-1,qd X 9 wk)markedly lowered systolic blood pressure and left ventricular(LV) weight,Study on isolated working heart demonstrated that the Tet group compared with the LVH group, AP,LVSP, ±dp/dtmax, LVDP,coronary blood flow and cardiac output were increased while LVEDP andT were decreased. Studies on LV pressure-volume relation showed that Tet can markedly improve theLV compliance and the LV stiffness constant of LVH ra. These findings suggest that the regression ofLVH in DOCA-salt hypertensive rats with Tet is associated with improvement of the contraction,relaxation and pump function , especially relaxation function and hemodynamics.

关 键 词：粉防己碱 左心室顺应性 左室肥厚 血液动力学 

分 类 号：R285.5[医药卫生—中药学] R972[医药卫生—中医学]