γ－去氢骆驼蓬碱等咔啉类生物碱的辐射防护作用  

KADIOPROTECTIVE EFFECT OF γ-HARMINE AND ITS CARBOLINE ANALOGUES

作　　者：利国威[1] 桑培根 潘国英[1] 

机构地区：[1]中山医科大学肿瘤防治中心

出　　处：《药学学报》1995年第9期715-717,共3页Acta Pharmaceutica Sinica

摘　　要：γ－去氢骆驼蓬碱等咔啉类生物碱的辐射防护作用利国威，桑培根，潘国英（中山医科大学肿瘤防治中心广州５１００６０）从新疆产蒺藜科植物骆驼蓬（ＰｅｈａｎｕｍｈａｒｍａｌａＬ．）的种子中分离得到３个化合物，其中γ－去氢骆驼蓬碱（γ－ｈａｒｍｉｎｅ，Ⅰ）为新化...γ- Harmine(Ⅰ),’ harmine(Ⅱ )and harmaline(Ⅲ )were isolated from PeganumHarmala L.( Zygophylaceae).Tests were conducted with mice to detect whether γ- harmine( a newcompound), harmine,harmof(Ⅳ)and harmalol(Ⅴ) are effective radioprotective compounds againstγ-ray irradiation, Intraperitoneal injection of the hydrochlorides of the four alkaloids 50～80mg·kg-1×1 in NIH male mice 30～45 minutes before 8.6～9. 7 Gy whole body 60Co irradiationsignificantly increased the survival effects(1. 33～2. 61)and 30-day survivai rate in comparison withcontrol mice.The results indicatethat γ- harmine exhibited relatively good radioprotective effect.γ-harmine is the first alkaloid isolated from a plant having ptotective effects against whole-body lethal irradiation in mice。

关 键 词：骆驼蓬 r-去氢骆驼蓬碱 咔啉类生物碱 抗辐射 

分 类 号：R282.710.5[医药卫生—中药学]