MK801慢性处理引起皮层神经元3H—GABA释放的改变  

INCREASE OF 3H-GABA RELEASE FROM RAT CULTURED CORTEX NEURONS AFTER CHRONIC EXPOSURE TO MK801

作　　者：施李正 钮心懿[1] 

机构地区：[1]中国医学科学院,中国协和医科大学药物研究所

出　　处：《药学学报》1995年第10期789-791,共3页Acta Pharmaceutica Sinica

摘　　要：ＭＫ８０１慢性处理引起皮层神经元￣３Ｈ－ＧＡＢＡ释放的改变施李正，钮心懿（中国医学科学院，中国协和医科大学药物研究所１０００５０，北京）某些急性和慢性神经退行性病变及精神紊乱与兴奋性氨基酸（ＥＡＡｓ）有关［１］。因此，发展专一性强、效能高并毒性低的兴...Excitatory amino acids are involved in acute and chronic neurodegenerativediseases.Little is known about the potential consequences of chronic blockade of NMDA receptors (onesubtype of excitatory amino acid receptors).Receptor function measured as 3H-GABA release inculture media after pretreatment with MK801 was studied in rat cortical neurons in primary cultures.Cultured neurons were exposed to 1μmol·L-1 MK801 for 4 days since the 14th day.Glutamate( 1 mmol·L-1 )evoked 3H-GABA release was shown to be significantly increased(control0.2174‰±1.40 ‰; MK801 treatment 0.763%±0.192%).KCl 40 mmol·L-1 stimulation showedno such effect.This result suggests that the NMDA receptor function of releasing neurotransmitterschanged after chronic treatment with noncompetitive antagonists.

关 键 词：R-氨基丁酸 3H 神经元 MK801 

分 类 号：R964[医药卫生—药理学]