高效液相色谱法测定氨苄青霉素血药浓度及药代动力学研究  

Determination of ampicillin in human plasma and its pharmacokinetics by high pressure liquid chromatography

作　　者：何树庄[1] 朱秀英[1] 葛兰波[1] 杨军[2] 田喜书 赵宏光 

机构地区：[1]哈尔滨医科大学临床药学药物研究所 [2]天津市第二中心医院 [3]沈阳药学院药学系

出　　处：《中国药学杂志》1989年第12期736-738,共3页Chinese Pharmaceutical Journal

摘　　要：本文采用高效液相色谱(HPLC)法测定氨苄青霉素的血药浓度,方法简便、快速、准确。并对静滴氨苄青毒素的药代动力学进行了探讨,证明此药的药代动力学属二室模型。A reversed high-pressure liquid chromatogra-phic assay was used for quantitative analysis of am-picillin in human plasma.With this method we st-udied pharmacokinetics of ampicillin with iv-dripand the results shewed that ampicillin belongs tothe pattern of two-compartment.The methodproved the to be easy,ragid and precise for the cli-nical monitoring of ampicillin concentration in plas-ma.

关 键 词：氨苄青霉素 血药浓度 药代动力学 

分 类 号：R969.1[医药卫生—药理学]