银屑病患者血清唾液酸及纤维结合蛋白变化的研究  

Study about Alteration of Serum Sialic Acid and Fibronectin in Psoriasis Patients

作　　者：王尚兰[1] 吴良章[1] 叶镝[1] 薛竞[1] 陈光荣[2] 何德秀[2] 

机构地区：[1]四川省人民医院皮肤科 [2]四川省人民医院检验科

出　　处：《医学科技》1995年第30期38-41,共4页

摘　　要：本文通过血清唾液酸快速比色法、蒋氏改良间苯二酚法及免疫琼脂单扩法测定45名正常人,50例银屑病患者和50例其他皮肤病人血清SA、ISA和Fn,结果表明银屑病血清SA、LSA和Fn均明显升高,与对照组及其他皮肤病组比较有显著差异(P<0.01),治疗前后血清SA、LSA和Fn也有显著差异(P<0.01),提示银屑病表皮细胞的分裂与唾液酸增减密切相关。同时还表明血浆Fn含量升高可能是机体表皮角朊细胞增殖、分化过快的调节作用的反应。因此,系统测定血清中 SA、LSA和Fn不仅有助于银屑病发病机理探讨,而且对疾病的诊断、疗效的观察都有很大帮助。This article reported the values of sialic acid (SA), lipid -- bound sialic acid (LSA)and fibronectin (Fn) in serum determined by serum sialic acid rapid colorimetric method,Kato Podis modification and simple agar immunodifussion test in 45 normal controls, 50psoriasis patients and 50 patients with other dermatologic diseases.The result showed thatall the SA, LSA and Fn were markedly elevated in psoriasis patients and had significantdiffevence in comparison with the control group and the group of dermatologic diseases (P< 0. 01). The significant difference also presented before and afer treatment (P < 0. 01).This showed that there was close relationship between psoriasis epidermic cells divisionand the alteration of SA. And the elevation of serum Fn value may be a reaction in the rgeu-lation of the rapid proliferation and differentiation of keratinocytes. So the determination ofserum SA, LSA and Fn is an useful approach to study the pathogenesis of psoriasis, andalso helpful to the diagnosis and evaluation of therapeutic effects.

关 键 词：银屑病 血清 唾液酸 纤维结合蛋白 

分 类 号：R758.630.2[医药卫生—皮肤病学与性病学]