豚鼠胃平滑肌上不同亲和力的毒蕈碱受体  

FUNCTIONAL DISTRIBUTION OF MUSCARINE RECEPTORS ON GASTRIC SMOOTH MUSCLES IN THE GUINEA-PIG

作　　者：阮英[1] 李智[1] 丛华[1] 张克义[1] 赫梅生[1] 

机构地区：[1]中国医科大学药理学教研室

出　　处：《中国医科大学学报》1989年第2期89-92,共4页Journal of China Medical University

基　　金：国家自然科学基金

摘　　要：采用离体功能实验,测定豚鼠胃底、体、窦部纵、环平滑肌由乙酰胆碱和阿托品引起的PD_2及PA_2。胃底、体部纵、环肌间的PD_2和PA_2差异非常显著,而窦部数值相近。结果提示:胃底、体部纵、环肌上可能存在高、低两种不同亲和性的毒草碱受体,胃窦部则以低亲和性毒蕈碱受体为主。With functional experiments in vitro, we observed PD_2 & PA_2 values of atropine & Ach, for longitudinal and circular smooth muscles in gastric fundus, body & antrum of guinea-pig. PD_2 % PA_2 values of longitudinal muscles were significantly different from those of circular muscles in the body & fundus, but similar in the antrum. The maximum contraction of longitudinal &. circular muscles in antrum was less than that in other regiors. The result indicated that two kinds of muscarine receptors with low & high affinities might exist in the body & fundus of the stomach, while in the antrum there mainly were muscarine receptors with low affinity.

关 键 词：胃平滑肌 毒蕈碱受体 乙酰胆碱 鼠 

分 类 号：R965[医药卫生—药理学]