SOTALOL对新生犬心肌浦肯野纤维电生理特性的影响  

THE ELECTROPHYSIOLOGIC EFFECTS OF SOTALOL ON THE ACTION POTENTIAL OF THE NEONATAL CANINE PURKINJE'S FIBERS

作　　者：徐惠[1] 李金鸣[2] 于艳风 王玉萍[2] Herry Gelband Arthur S. Pickoff Adrienne Stilfi 

机构地区：[1]中国医科大学附属第一医院儿科 [2]中国医科大学药理学教研室 [3]美国迈阿密大学儿科心血管研究所

出　　处：《中国医科大学学报》1989年第3期206-211,共6页Journal of China Medical University

摘　　要：Sotalol是具有明显Ⅲ类作用的β—受体阻断药。我们用标准玻璃微电极技术,观察Sotalol对新生犬心肌浦肯野纤维电生理特性的影响。与成年犬对比,Sotalol对新生犬心肌浦肯野纤维具有显著的Ⅲ类抗心律失常作用的特性。Sotalol is a new beta-blocking agent which has also been shown to exert a significant class Ⅲ action.We have investigated the electrophysiologie effects of sotalol on the isolated purkinje's fibers of the immature canine heart utilizing intracellular microelectrode techniques. By comparing the changes observed in the neonatal purkinje's fibers exposed to sotalol with those recorded from purkinje's fibers of adult canine, We show that the neonatal purkinje's fibers exhibits an enhanced sensitivity to the class Ⅲ actions of this drug.

关 键 词：SOTALOL 新生犬 心肌细胞 电生理 

分 类 号：R972.2[医药卫生—药品]