高氟区骨龄延迟青少年血清hGH对L-dopa和Inderal反应的研究  

PLASMA GROWTH HORMONE RESPONDING TO L-DOPA AND INDERAL IN ADOLESCENT WITH RETARD OF SKELETAL AGE IN AN AREA OF HIGH FLUORIDE DRINKING WATER

作　　者：齐今吾[1] 赵晓娟[1] 冯洪刚[1] 戴国钧[2] 钱聪[2] 李晶[2] 成金山 高洪信 马春林 魏景阳 苏广民 

机构地区：[1]中国医科大学附属一院内分泌研究室 [2]中国医科大学预防医学系流行病学教研室 [3]内蒙古赤蜂市地方病防治所 [4]内蒙古敖汉旗卫生防疫站

出　　处：《中国医科大学学报》1989年第6期459-462,共4页Journal of China Medical University

基　　金：国家自然科学基金

摘　　要：本文探讨高氟区骨龄延迟青少年血清hGH对L-dopa及Inderal双重刺激的反应。结果发现其高峰反应值较同地区及非高氟区骨龄正常青少年明显减低(p<0.01),提示高氟可能作为影响hGH的分泌释放因素。并结合实验原理初探其发生机理。Plasma human growth hormone (hGH) response to L-dopa and Inderal on endemic fluoride-induced retard of skeletal age in adolescent is discribed in this paper. The results showed that the peak levels of serum hGH in skeletal age retard group in the fluorosis area responding to oral administration of L-dopa and Inderal were significantly lower than those of the groups with normal skeletal age (p<0.01). These findings indicated that the endemic high fluoride was an important factor for inducing retard sheletal of age in adelescent, which might inhibit secreting releasing of hGH.

关 键 词：氟中毒 骨龄 HGH 左旋多巴 心得安 

分 类 号：R595.102[医药卫生—内科学]