十一酸睾丸素与达那唑合用对雄性大鼠的抗生育作用  

Studies on Antifertility Effect of Testosterone Undecanoate in Combination with Danazol in Male Rats

作　　者：吕志良 杨宝珠 方瑞英 

机构地区：[1]中国医学科学院浙江分院

出　　处：《中国医学科学院学报》1989年第3期190-194,共5页Acta Academiae Medicinae Sinicae

摘　　要：给雄性大鼠肌注十一酸睾丸素,同时用达那唑灌胃,观察睾丸及附睾的形态与功能变化,以评价其抗生育作用。给药35d.睾丸及曲细精管径缩小,附睾尾精子活力显著降低,睾丸内睾丸素及附睾内蛋白质与磷脂含量均明显下降;给药75d,生精过程受抑,严重少精或无精,交配雌鼠生育率0％。停药100d后,上述变化均恢复正常,附睾管腔精子充盈,生育率100％。表明TU与DZ合用具有可逆性抗生育作用,其作用机理主要是由于降低睾丸内睾丸素水平,从而使精子生成及存活受抑。Male rats were injected i.m. with 12 mg/kg testosterone undecanoate (TU) twice in the first and once in each of the succeeding 2 months in combination with oral danazol (DZ) of 30 mg/kg/day. Antifertility effects were observed with morphorlogical and functional techniques for half a year. Results showed: reduction of testis weight and seminiferous tubule diameter: decrease of sperm viability and motility in canda epididymidis; and lowering of testosterone levels in testis and phospholipid and protein contents in epididymis. 7b days after treatment spermatogensis was arrested mainly in the secondary spermatocyte stage with a decrease in sperm count to 0 in the canda epididymidis. Mating test showed 0% fertility. Testicular testosterone and epididymis phospholipid and protein contents were found to have dropped further. However, all of the above-mentioned changes recovered completely 100 days after cessation of treatment. The authors suggest that TU plus DZ in a suitable dose suppresses spermatogensis, retards maturation and shortens the survival time of sperm in the epididymis by reducting testosterone levels in the testis.

关 键 词：十一酸睾丸素 达那唑 抗生育作用 

分 类 号：R979.21[医药卫生—药品]