环磷酰胺对乙脑灭活疫苗和减毒活疫苗免疫效果的比较  

Effect of Cytoxan on Immune Response of Japanese Encephalitis Virus Killed and Live Vaccines

作　　者：房强[1] 陈伯权[1] 

机构地区：[1]中国预防医学科学院病毒学研究所

出　　处：《中国医学科学院学报》1989年第5期317-321,共5页Acta Academiae Medicinae Sinicae

摘　　要：用环磷酰胺分别抑制乙脑灭活疫苗和减毒活疫苗免疫小鼠的免疫系统,比较观察免疫抑制对两种疫苗免疫效果的影响.实验发现,灭活疫苗三次接种免疫抑制后其免疫保护率由100％降至20％;而减毒活疫苗2-8株和5-3株的免疫效果没受环磷酰胺的影响.经过了二次接种,其保护率仍为100％.实验结果证明了应用减毒活疫苗有一定的优越性.Mice vaccinated by Japanese encephalitis (JE) virus killed and live vaccines respectively were injected subcutaneously with cytoxan (1.5mg/10g weight) once every two days for 3 times, and then challenged by JE virus virulent A2 strain. The results showed that the protective rate of killed vaccine (inoculated 3 times) was decreased from 100% to 20% after cytoxan immunosuppression, while that of live vaccines 2-8 strain and 5-3 strain (inoculated 2 times) still remained 100% as in the control group without cytoxan. The results indicate that the immune response induced by the killed vaccine can be easily damaged by cytoxan, but that induced by the live vaccines not, suggesting of important advantage of JE virus live vaccine. Our results implies that the JE incidence being higher in old subjects probably is related to the declining of immune function.

关 键 词：乙型脑炎 疫苗 免疫抑制 环磷酰胺 

分 类 号：R512.320.1[医药卫生—内科学]