锌缺乏及补锌对发育仔鼠脑内锌、铜和铁浓度的影响  

EFFECTS OF Zn DEFlCIENCY AND SUPPLE,ENTATION ON THE CONCENTRATIOoNS OF Zn Fe AND Cu IN DEVELOPING RAT DRAlN

作　　者：谢良民[1] 赵法[1] 郭俊生[1] 奚建华[1] 

机构地区：[1]上海第二军医大学军队卫生学教研室

出　　处：《营养学报》1995年第2期174-179,共6页Acta Nutrimenta Sinica

基　　金：研究生经费

摘　　要：本文研究了发育大鼠小脑、大脑皮质和海马内微量元素锌、铜和铁浓度的发育性改变，以及膳食锌缺乏和补锌对其影响。发育鼠脑内的锌、铁和铜的分布不均一，其浓度随年龄增加而增高。３０天龄大鼠小脑、大脑皮质和海马中的锌浓度比２１天龄时显著减低。锌缺乏对脑内锌和铁浓度无显著影响，但可以引起脑内铜浓度显著增高。锌缺乏仔鼠２１天龄断乳后开始补锌，至３０天龄脑内铜浓度仍显著高于正常对照仔鼠。结果表明，锌缺乏引起脑铜浓度改变可能是发生锌缺乏症时神经功能发生改变的原因之一。he ontogenetic alterations in the concentrations of trace elements Zn,Cu and Fe in the selected regions of cerebrum,cerebellum and hippocampusin developing rat brain had been studied.The distributions of Zn,Cu andFe in the developing rat brain were not uniform and their contents increasedwith age. The concentrations of Zn at 30 days after birth were significantlylower (P<0.05) than that at 21 days postpartum,Zn deficiency caused anelevation in Cu concentrations in cerebellum,cerebrum and hippocampus.It suggested that the changes in brain Cu,may contribute to neural functionalalterations accompanying zinc deficiency.

关 键 词：脑发育 锌 铁 铜 锌缺乏 记忆功能 

分 类 号：R591.102[医药卫生—内科学]