鼠大脑皮层感觉运动区及锥体外系参与中缝大核痛调制机制的分析  

The Analysis of the Mechanisms of Both the SM and the Extrapyramidal System Modulating the Nociceptive Responses of the Neurons in NRM

作　　者：邹挺[1] 刘乡[1] 

机构地区：[1]中国中医研究院针灸研究所

出　　处：《针刺研究》1995年第1期5-9,共5页Acupuncture Research

摘　　要：本实验记录鼠NRM神经元的单位放电，观察到损毁尾核头部前刺激SM后肢区，能明显激活NRM神经元和显著抑制NRM神经元的伤害性反应；而在损毁尾核头部后刺激SM，这两种效应几乎消失，提示刺激SM后肢区对NRM的效应可能是经尾核头部中继的，结合以往的工作，对SM通过锥体系与锥体外系两条途径参与痛调制的机制进行了讨论。The experiment was carried out on rats. Unit d1scharges of NRM were recorded extracellularly with glass microelectrode.Before the lesion of the head of N.Caudatus,15 NRM neurons were recorded.The stimulation of the hindlimb areas of SM could obviously activate NRM neurons,the spontaneous discharges were increased to 59.06±25. 35 % (P<0.05) and the nociceptive responses were obviously inhibited to-46. 61±14.78 (P<0.01) at 0minute after stopping stimulation, Both effects lasted for 15 minutes,and then gradually returned to original level.After the lesion of the head of N. Caudatus,the effects of the stimulation of the hindlimb areas of SM on 19 NRM neurons were clearly decreased.The spontaneous discharges were increased to only 6. 9±21. 46 % and thenociceptive responses were inhlbited only - 4. 57±11.08 % at 0 minute after stopping stimulation,even the nociceptive responses were slightly increased in 5 - 30 minutes, The difference between the two groups was statistical significance,The value of the difference was about 42 % (P<0.05 ) at 0 minute and lasted 30 minutes.It suggests that the effects of stimulating SM on NRM may be transmitted by the head of N. Caudatus in the extrapyramidal system

关 键 词：中缝大核 大脑皮层 感觉运动区 痛觉调制 电针 

分 类 号：R245－0[医药卫生—针灸推拿学]