损毁大鼠SmI区后微电泳吗啡对丘脑束旁核神经元伤害性反应的影响  

Influence of Microiontophoretic Morphine on Nociceptive Responses of Pf Neurons after Lesion of SmI

作　　者：郑欣[1] 陈正秋[1] 石宏[1] 徐维[1] 

机构地区：[1]中国中医研究院针灸所,北京100700

出　　处：《针刺研究》1995年第3期18-21,共4页Acupuncture Research

摘　　要：用五管微电极细胞外记录的方法，观察在损毁皮层体感运动Ⅰ区（SmI）的条件下，微电泳导入吗啡对丘脑束旁核（Pf）神经元电活动的影响。结果显示：微电泳吗啡后6’－8’Pf神经元的伤害性反应明显减弱，与盐水对照组相比，两组神经元伤害性反应的差别有显著意义。提示：阿片肽参与Smi对Pf神经元的下行性调节。Neuronal responses in thalamic nucleus parafasciculus (Pf) to microiontophoretic rnorphine wereexamined in 20 wistar rats after lesion of SmI. Extracellular recordings were rnade with five-barreledglass microelectrodes. The results showed that the spontaneous responses of Pf neurons were not statistically changed (n= 11, P>0.05), but their nociceptive responses were attenuated at 0- 8 min utes after iontophoretic morphine (n=11, P<0. 05 ). There were statistically significant differencesin nociceptive responses between morphine and saline groups at 0-8 minutes after iontophoresis. Theresults suggest that morphine may be involved in corticofugal modulation of nociceptive responses inthalamic Pf neurons.

关 键 词：吗啡 丘脑束旁核 皮层下行调节 微电泳 针刺镇痛 

分 类 号：R245－0[医药卫生—针灸推拿学]