二氢甲烷毒理实验研究  

Toxicological Examinations of Dichloromethane

作　　者：康忠玉[1] 

机构地区：[1]四川省劳动卫生职业病防治研究所

出　　处：《职业卫生与病伤》1995年第3期132-135,共4页Occupational Health and Damage

摘　　要：二氯甲烷对大小鼠急性毒性ＬＣ（５０）为７４７６０和５１８６０ｍｇ／ｍ３，大鼠蓄积系数大于５（６．３）；家兔经皮吸收后２～３ｈ血中ＣＯＨｂ％达高峰，７～８ｈ恢复正常，对兔眼结膜有较强的刺激，大鼠、豚鼠慢性浓度在２８００ｍｇ／ｍ３以上，可使ＯＣＴ、ＢＵＮ、ＴＧ和血中ＣＯＨｂ％升高，使巨噬细胞吞噬功能降低，二氯甲烷浓度１０３７２和５１８６ｍｇ／ｍ３可使致突变指数大于１５；在１７００ｍｇ／ｍ３以上使骨髓细胞微核率升高明显；无明显的致畸和胚胎毒作用．The toxicological examinations of dichloromethane were reported in this paper. TheLC50s for dichloromethane in rat and mouse were 74760and 51860 mg/m3,respectively. Thecumulation coefficient in rat was greater than5(6. 3).The level of HbCO%in blood of rab-bits reache the maximum 2～3 h and recovered normal 7～8 h after cutaneous exposure, therewas a intensive irritation to eye's mucous membrane of rabbits. The levels of OCT, BUN,TG,and HbCO%in blood were increased at concentration above 2800mg/m3 in rats andguinea pigs, Dichloromethane reduced the swallow function of macrophage, The mutagenicindexes were greater than 15 at 10372and 5186 mg/m3, respectively. The frequencies of mi-cronucleus in bone marrow cells increased at comcentration above 1700 mg/m3. There wereno clear teratogenicity and embryonic toxicity.

关 键 词：二氯甲烷 毒理 工业毒理学 

分 类 号：R994.3[医药卫生—毒理学]