红毛五加多糖对心肌肥厚大鼠早期心肌ATP酶和免疫功能的影响  

Effect of Girald Acanthopanax (Acanthopanax giraldii) Polysaccharide on Myocine ATPase and Immunity of Myocardial Hypertrophy Rat in Vivo

作　　者：杜力军[1] 马立焱[1] 於兰[1] 国月英[2] 

机构地区：[1]中国医学科学院药用植物研究所,北京100094 [2]中国中医研究院西苑医院

出　　处：《中草药》1995年第7期362-363,365,共3页Chinese Traditional and Herbal Drugs

摘　　要：以狭窄腹主动脉方法所致大鼠早期心肌肥厚模型显示，在大鼠尾动脉血压升高，左心室壁增厚的同时，出现胸腺、脾T细胞增殖能力降低，IL－2分泌量也明显下降。同时左心室肌球蛋白ATP酶活力下降，红毛五加多糖10mg／kg·d皮下注射在提高ATP酶活性的同时，能部分地升高其免疫水平，提示该药对由于心肌肥厚所出现的免疫抑制现象及增强心肌代偿能力具有一定的药理作用。It was shown that in the stricture on abdominal aorta (SAA) rat myocardiac hypertrophy model,the caudal blood pressure was increased,the wall of left ventricle was thichened, the proliferation of T cell in thymus and spleen was decreased and the content of IL-2 was less than normal. Acanthopanax giroldii polysaccharide (AGPS10mg/kg.d, sc) could harmonize the heightened blood pressure and increase the level of immunity in the body. It was suggested by the result, that AGPS could be used to strengthen the heart function as well as immunity.

关 键 词：心肌肥厚 红毛五加多糖 免疫功能 心肌ATP酶 

分 类 号：R282.710.5[医药卫生—中药学]