粗壮女贞的降压作用  

Hypotensive Action of Cuzhuangnuzhen (Ligus trum robustum)

作　　者：陈一[1] 何兴全[1] 谢唐贵[1] 李翠红[1] 

机构地区：[1]广西中医药研究所,南宁530022

出　　处：《中草药》1995年第7期360-361,共2页Chinese Traditional and Herbal Drugs

摘　　要：粗壮女贞叶提取物静脉注射0．098、0．140和0．200g／kg可使麻醉大鼠的血压显著下降，峰值下降37．7％、38．6％和50．2％：灌胃给药（ig）1．36g／kgqd×3d，不影响清醒大鼠的血压。清醒自发性高血压大鼠ig1．08和2．16g／kgqd×5d，血压由24．3±0．5和24．3±0．6降至18．1±0．9和16．6±0．7kPa，降压作用显著（P＜0．001，＜0．001）；对清醒二肾-夹型高血压大鼠，ig粗壮女贞0．5g／kgqd×7d，血压由20．3±3．9降至16．2±3．9kPa，血压下降20％。以上结果提示具有降压作用。昆明小鼠急性毒性试验，ig49g／kg10d内动物生长良好，未出现死亡；腹腔注射5个剂量组（每组10只）按简化机率单位法测得LD502．64±0．21g／kg（P＝0．95）。When an extract of the leaves of Ligustrum robustum was given to anesthetized rats intravenously at doses of 0.098, 0.140, 0.200 g/kg the BP of the animals decreased rapidly by 37.7,38.6 and 50.2% respectively. But without any effect when given intragastrically to conscious rats at 1.36g/kg (qid × 3d ). When conscious spontaneous hypertensive rats were given this extract intragastrically at 1.08 and 2.16g/kg (qid ×5d) their BP decreased to 18.1 ±0.9 and 16.6± 0.7kPa from 24.3±0.5 and 24.3±0.6kPa res pectively (P<0.001, P<0.001).when 2 kidney 1 clip hypertensive rats were treated with this extract ig at 0.5g/kg(qid × 7d),the BP decreased to 16.2±3.9kPa from 20.3×3.9kPa. These results indicated that L. robustum has hypotensive activity.Acute LD50 of the extract of the leaves of L. robustum intraperitoneally to mice was 2.64±0.21g/kg.

关 键 词：粗壮女贞 高血压 降压作用 

分 类 号：R282.710.5[医药卫生—中药学]