G9315抗促癌和抑制促癌物诱发的脂质过氧化作用  

Antipromoting Tumor and Antioxidant Actions of G_(9315)

作　　者：傅乃武[1] 刘朝阳[1] 张如意[2] 

机构地区：[1]中国医学科学院肿瘤研究所,北京100021 [2]北京医科大学药学院植化室

出　　处：《中草药》1995年第8期411-413,422,共4页Chinese Traditional and Herbal Drugs

摘　　要：G9315是从胀果甘草中提取的含有6个黄酮体的混合物。2mg剂量明显抑制二甲基苯蒽（DMBA）合并巴豆油诱发的小鼠皮肤乳头瘤的生成，表现出较强的抗促癌作用。10μg／ml显著抑制巴豆油诱发的Wistar大鼠中性粒细胞化学发光（chemiluminescence，CL），20μg／ml明显抑制巴豆油诱发的Balb／c新生小鼠皮肤表皮细胞和Balb／c小鼠肝线粒体的CL，显著对抗巴豆油诱发的Balb／c小鼠肝线粒体的脂质过氧化、使丙二醛（MDA）产量明显减少。G9315 was a complex extracted from Glycyrrhizae inflate Batal, and consisted of 6 flavonoids with significant antioxidant effects. At 2mg dose, it showed strong antipromoting effect on two stage carcinogenesis in mouse skin induced by DMBA plus croton oil. At 10μg/ml dose, it inhibited the chemiluminescence (CL ) of polymorphonuclear leukocyte (PMN ) of Wistar rat induced by croton oil, at 20 μg/ml, it inhibitcd the CL of new born Balb/c mouse epidermis and liver mitochondria induced by croton oil. It also inhibited the CL of Balb/c mouse microsome induced by CCl4.

关 键 词：G9315 化学发光 脂质过氧化 黄酮体 抗促癌作用 

分 类 号：R285.5[医药卫生—中药学]