肽6A对球囊损伤后大鼠主动脉血管壁增殖的影响  

Effect of peptide 6A on vascular cell proliferation induced by balloon angioplasty in rat aorta

作　　者：姚兴海[1] 凌世长 田青[1] 付爱华[1] 汤健[1] 唐朝枢[1] 刘勃[1] 朱国英[1] 赵明[1] 彭师奇[1] 王秉瑞[1] 吴祥林[1] 

机构地区：[1]北京医科大学心肺内分泌研究室,北京医科大学第一临床医学院,天然药物与仿生药物国家重点实验室,卫生部兰州生物制品研究所

出　　处：《中国病理生理杂志》1995年第1期26-29,共4页Chinese Journal of Pathophysiology

摘　　要：本文在大鼠主动脉球囊内皮剥脱术后血管壁细胞过份增殖模型上，用合成的纤维蛋白（原）降解产物肽６Ａ（４０μｍｏｌ／ｋｇ／ｄ）治疗，可有效地抑制损伤血管壁的细胞计数增加和内膜增殖，显著降低其血管组织￣３Ｈ－ＴｄＲ和￣３Ｈ－Ｌｅｕ掺入增加程度，实验结果提示肽６Ａ作为血管成型术的辅佐剂，对于防治再狭窄可能具有潜在临床应用前景。A vascular cell proliferation model was established by balloon angioplastyin rat aorta treated with synthetic peptide 6A(40 μmol/kg/day ),which is a degradationproduct of fibrinogen,the increase in cell count of injuried vascular wall, and incorpor-ation of￣3H-TdR and ￣3H-Leu of vascular tissues were inhibited effectively.These resultssuggest that peptide 6A as an adjuvant of balloon angioplasty might have clinically pros-pective significance in preyention and therapy of restenosis.

关 键 词：主动脉 血管壁细胞增殖 肽6A 球囊损伤 

分 类 号：R543.105[医药卫生—心血管疾病] R965.1[医药卫生—内科学]